ACP Journal Club. Preexposure prophylaxis reduced HIV-1 spread in serodiscordant heterosexual couples.

Patients: 4758 HIV-1 seronegative partners with HIV-infected partners (heterosexual couples) ≥ 18 years of age (62% of HIV1–negative partners were men, 97% of couples were married). Seropositive partners had CD4 cell counts ≥ 250 cells/mm3 and were not receiving or meeting local guidelines for antiretroviral therapy at enrollment. Seronegative partners had normal renal function (creatinine clearance ≥ 60 mL/min, and serum creatinine ≤ 1.3 mg/dL for men and ≤ 1.1 mg/dL for women) and were not pregnant, breastfeeding, or infected with hepatitis B virus.